diff --git a/doc/source/changelog.rst b/doc/source/changelog.rst
index e2676c9e8..77bd94c11 100644
--- a/doc/source/changelog.rst
+++ b/doc/source/changelog.rst
@@ -17,6 +17,10 @@ organisation on `GitHub <https://github.com/openbiosim/sire>`__.
 
 * Please add an item to this CHANGELOG for any new features or bug fixes when creating a PR.
 
+* Run each ``Dynamics.run()`` block through to the next frame or energy save rather than
+  in fixed blocks of 50 steps, which cost a force evaluation and a GPU sync each. The 50
+  step blocks are kept when a progress bar is shown, since they only exist to update it.
+
 `2026.2.0 <https://github.com/openbiosim/sire/compare/2026.1.0...2026.2.0>`__ - September 2026
 ----------------------------------------------------------------------------------------------
 
diff --git a/src/sire/base/_progressbar.py b/src/sire/base/_progressbar.py
index 219c05781..870234fde 100644
--- a/src/sire/base/_progressbar.py
+++ b/src/sire/base/_progressbar.py
@@ -3,6 +3,7 @@
 from ..legacy.Base import ProgressBar as _ProgressBar
 
 _cached_in_notebook = None
+_is_silent = False
 
 
 def _in_notebook():
@@ -113,4 +114,10 @@ def set_theme(theme):
 
     @staticmethod
     def set_silent():
+        global _is_silent
+        _is_silent = True
         _ProgressBar.set_silent()
+
+    @staticmethod
+    def is_silent():
+        return _is_silent
diff --git a/src/sire/mol/_dynamics.py b/src/sire/mol/_dynamics.py
index 383300078..545d14090 100644
--- a/src/sire/mol/_dynamics.py
+++ b/src/sire/mol/_dynamics.py
@@ -1405,35 +1405,31 @@ class NeedsMinimiseError(Exception):
 
                 with ThreadPoolExecutor() as pool:
                     while completed < steps_to_run:
-                        block_size = 50
+                        # Each block ends at the next frame or energy save, or the end
+                        # of the run. Shorter blocks are only needed to update the
+                        # progress bar, and cost a GPU sync each.
+                        block_size = steps_to_run - completed
+                        if not ProgressBar.is_silent():
+                            block_size = min(block_size, 50)
 
                         steps_till_frame = self._next_save_frame - (
                             completed + nsteps_before_run
                         )
-                        if steps_till_frame <= 0 or (
-                            steps_till_frame <= block_size
-                            and steps_till_frame <= steps_to_run - completed
-                        ):
-                            save_frame = True
-                            self._next_save_frame += frame_frequency_steps
-                            if frame_frequency_steps < block_size:
-                                block_size = frame_frequency_steps
-                        else:
-                            save_frame = False
-
                         steps_till_energy = self._next_save_energy - (
                             completed + nsteps_before_run
                         )
-                        if steps_till_energy <= 0 or (
-                            steps_till_energy <= block_size
-                            and steps_till_energy <= steps_to_run - completed
-                        ):
-                            save_energy = True
+                        if 0 < steps_till_frame < block_size:
+                            block_size = steps_till_frame
+                        if 0 < steps_till_energy < block_size:
+                            block_size = steps_till_energy
+
+                        save_frame = steps_till_frame <= block_size
+                        if save_frame:
+                            self._next_save_frame += frame_frequency_steps
+
+                        save_energy = steps_till_energy <= block_size
+                        if save_energy:
                             self._next_save_energy += energy_frequency_steps
-                            if energy_frequency_steps < block_size:
-                                block_size = energy_frequency_steps
-                        else:
-                            save_energy = False
 
                         # save the last frame if we're about to exit and the user
                         # has requested it