diff --git a/CHANGELOG.md b/CHANGELOG.md
index 419a8a7c63d..d9e48cd6df8 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -13,6 +13,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   
 ### Added
 
+- `opentelemetry-instrumentation-asgi`: Respect `suppress_http_instrumentation` context in ASGI middleware to skip server span creation when HTTP instrumentation is suppressed
+  ([#4375](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4375))
 - `opentelemetry-instrumentation-confluent-kafka`: Loosen confluent-kafka upper bound to <3.0.0
   ([#4289](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4289))
 - `opentelemetry-instrumentation`: Add support for wrapt 2.x
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
index 59c5083ada8..e28315f502e 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
@@ -255,7 +255,10 @@ def client_response_hook(span: Span, scope: Scope, message: dict[str, Any]):
 from opentelemetry.instrumentation.propagators import (
     get_global_response_propagator,
 )
-from opentelemetry.instrumentation.utils import _start_internal_or_server_span
+from opentelemetry.instrumentation.utils import (
+    _start_internal_or_server_span,
+    is_http_instrumentation_enabled,
+)
 from opentelemetry.metrics import get_meter
 from opentelemetry.propagators.textmap import Getter, Setter
 from opentelemetry.semconv._incubating.attributes.http_attributes import (
@@ -745,7 +748,10 @@ async def __call__(
             send: An awaitable callable taking a single dictionary as argument.
         """
         start = default_timer()
-        if scope["type"] not in ("http", "websocket"):
+        if not is_http_instrumentation_enabled() or scope["type"] not in (
+            "http",
+            "websocket",
+        ):
             return await self.app(scope, receive, send)
 
         _, _, url = get_host_port_url_tuple(scope)
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py b/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py
index f716c9f2f1e..b14f207d8a5 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py
@@ -37,6 +37,7 @@
     get_global_response_propagator,
     set_global_response_propagator,
 )
+from opentelemetry.instrumentation.utils import suppress_http_instrumentation
 from opentelemetry.sdk import resources
 from opentelemetry.sdk.metrics.export import (
     HistogramDataPoint,
@@ -1880,6 +1881,19 @@ async def test_no_excluded_urls(self):
         spans = self.get_finished_spans()
         self.assertGreater(len(spans), 0)
 
+    async def test_suppress_http_instrumentation(self):
+        app = otel_asgi.OpenTelemetryMiddleware(simple_asgi)
+
+        async def suppression_wrapper(scope, receive, send):
+            with suppress_http_instrumentation():
+                await app(scope, receive, send)
+
+        self.seed_app(suppression_wrapper)
+        await self.send_default_request()
+        await self.get_all_output()
+        spans = self.get_finished_spans()
+        self.assertEqual(len(spans), 0)
+
 
 class TestAsgiAttributes(unittest.TestCase):
     def setUp(self):