diff --git a/.changelog/5266.deprecated b/.changelog/5266.deprecated
new file mode 100644
index 00000000000..42e0816ea06
--- /dev/null
+++ b/.changelog/5266.deprecated
@@ -0,0 +1 @@
+`opentelemetry-instrumentation-botocore`: deprecate Bedrock runtime extension in favor of `opentelemetry-instrumentation-genai-bedrock`
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/README.rst b/instrumentation/opentelemetry-instrumentation-botocore/README.rst
index 61804f740bb..fa0001360f6 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/README.rst
+++ b/instrumentation/opentelemetry-instrumentation-botocore/README.rst
@@ -14,14 +14,20 @@ Extensions
 The instrumentation supports creating extensions for AWS services for enriching what is collected. We have extensions
 for the following AWS services:
 
-- Bedrock Runtime (botocore only)
+- Bedrock Runtime (botocore only) [Deprecated]
 - DynamoDB
 - Lambda
 - SNS
 - SQS
 
-Bedrock Runtime (botocore only)
-*******************************
+Bedrock Runtime (botocore only) [Deprecated]
+********************************************
+
+.. note::
+    The Bedrock extension in ``opentelemetry-instrumentation-botocore`` is deprecated
+    and will be removed in a future release. Please use `opentelemetry-instrumentation-genai-bedrock <https://pypi.org/project/opentelemetry-instrumentation-genai-bedrock/>`_.
+    When ``opentelemetry-instrumentation-genai-bedrock`` is active, this extension
+    is automatically suppressed to avoid duplicate telemetry.
 
 This extension implements the GenAI semantic conventions for the following API calls:
 
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/extensions/bedrock.py b/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/extensions/bedrock.py
index 61c54d629d2..a60a1e4c7f5 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/extensions/bedrock.py
+++ b/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/extensions/bedrock.py
@@ -8,9 +8,11 @@
 
 from __future__ import annotations
 
+import importlib.metadata
 import io
 import json
 import logging
+import warnings
 from timeit import default_timer
 from typing import Any
 
@@ -28,6 +30,7 @@
 )
 from opentelemetry.instrumentation.botocore.extensions.types import (
     _AttributeMapT,
+    _AwsSdkCallContext,
     _AwsSdkExtension,
     _BotoClientErrorT,
     _BotocoreInstrumentorContext,
@@ -102,6 +105,14 @@
 _MODEL_ID_KEY: str = "modelId"
 
 
+def _is_genai_bedrock_active() -> bool:
+    try:
+        importlib.metadata.version("opentelemetry-instrumentation-genai-bedrock")
+        return True
+    except importlib.metadata.PackageNotFoundError:
+        return False
+
+
 class _BedrockRuntimeExtension(_AwsSdkExtension):
     """
     This class is an extension for <a
@@ -120,10 +131,36 @@ class _BedrockRuntimeExtension(_AwsSdkExtension):
         "InvokeModelWithResponseStream",
     }
 
+    def __init__(self, call_context: _AwsSdkCallContext):
+        super().__init__(call_context)
+        if _is_genai_bedrock_active():
+            _logger.debug(
+                "opentelemetry-instrumentation-genai-bedrock is active; "
+                "suppressing botocore BedrockExtension to avoid duplicate spans."
+            )
+            self._handled_operations: set[str] = set()
+            self._dont_close_span_on_end_operations: set[str] = set()
+        else:
+            warnings.warn(
+                "The Bedrock extension in 'opentelemetry-instrumentation-botocore' is deprecated "
+                "and will be removed in a future release. "
+                "Please install 'opentelemetry-instrumentation-genai-bedrock' that would take over this extension.",
+                category=DeprecationWarning,
+                stacklevel=2,
+            )
+            self._handled_operations = self._HANDLED_OPERATIONS
+            self._dont_close_span_on_end_operations = self._DONT_CLOSE_SPAN_ON_END_OPERATIONS
+
+    @property
+    def _disabled(self) -> bool:
+        return not self._handled_operations
+
     def should_end_span_on_exit(self):
-        return self._call_context.operation not in self._DONT_CLOSE_SPAN_ON_END_OPERATIONS
+        return self._call_context.operation not in self._dont_close_span_on_end_operations
 
     def setup_metrics(self, meter: Meter, metrics: dict[str, Instrument]):
+        if self._disabled:
+            return
         metrics[GEN_AI_CLIENT_OPERATION_DURATION] = meter.create_histogram(
             name=GEN_AI_CLIENT_OPERATION_DURATION,
             description="GenAI operation duration",
@@ -158,7 +195,7 @@ def _extract_metrics_attributes(self) -> _AttributeMapT:
         return attributes
 
     def extract_attributes(self, attributes: _AttributeMapT):
-        if self._call_context.operation not in self._HANDLED_OPERATIONS:
+        if self._call_context.operation not in self._handled_operations:
             return
 
         attributes[GEN_AI_SYSTEM] = GenAiSystemValues.AWS_BEDROCK.value
@@ -376,7 +413,7 @@ def _get_messages_from_input_text(self, decoded_body: dict[str, Any], input_name
         return []
 
     def before_service_call(self, span: Span, instrumentor_context: _BotocoreInstrumentorContext):
-        if self._call_context.operation not in self._HANDLED_OPERATIONS:
+        if self._call_context.operation not in self._handled_operations:
             return
 
         capture_content = genai_capture_message_content()
@@ -540,7 +577,7 @@ def on_success(
         result: dict[str, Any],
         instrumentor_context: _BotocoreInstrumentorContext,
     ):
-        if self._call_context.operation not in self._HANDLED_OPERATIONS:
+        if self._call_context.operation not in self._handled_operations:
             return
 
         capture_content = genai_capture_message_content()
@@ -836,7 +873,7 @@ def on_error(
         exception: _BotoClientErrorT,
         instrumentor_context: _BotocoreInstrumentorContext,
     ):
-        if self._call_context.operation not in self._HANDLED_OPERATIONS:
+        if self._call_context.operation not in self._handled_operations:
             return
 
         span.set_status(Status(StatusCode.ERROR, str(exception)))
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/tests/cassettes/test_converse_suppressed_end_to_end_when_genai_active.yaml b/instrumentation/opentelemetry-instrumentation-botocore/tests/cassettes/test_converse_suppressed_end_to_end_when_genai_active.yaml
new file mode 100644
index 00000000000..255c3832b76
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-botocore/tests/cassettes/test_converse_suppressed_end_to_end_when_genai_active.yaml
@@ -0,0 +1,81 @@
+interactions:
+- request:
+    body: |-
+      {
+        "messages": [
+          {
+            "role": "user",
+            "content": [
+              {
+                "text": "Say this is a test"
+              }
+            ]
+          }
+        ],
+        "inferenceConfig": {
+          "maxTokens": 10,
+          "temperature": 0.8,
+          "topP": 1,
+          "stopSequences": [
+            "|"
+          ]
+        }
+      }
+    headers:
+      Content-Length:
+      - '170'
+      Content-Type:
+      - application/json
+      User-Agent:
+      - Boto3/1.35.56 md/Botocore#1.35.56 ua/2.0 os/macos#24.0.0 md/arch#arm64 lang/python#3.13.1
+        md/pyimpl#CPython cfg/retry-mode#legacy Botocore/1.35.56
+      X-Amz-Date:
+      - 20250206T051231Z
+      X-Amzn-Trace-Id:
+      - Root=1-c114b02b-84cec2d763a71299ae73fb9f;Parent=6f540fd45e1dc3b3;Sampled=1
+      amz-sdk-invocation-id:
+      - a8c71d0c-ae7b-4685-b696-6ba0ded398ef
+      amz-sdk-request:
+      - attempt=1
+      authorization:
+      - Bearer test_aws_authorization
+    method: POST
+    uri: https://bedrock-runtime.us-east-1.amazonaws.com/model/amazon.titan-text-lite-v1/converse
+  response:
+    body:
+      string: |-
+        {
+          "metrics": {
+            "latencyMs": 608
+          },
+          "output": {
+            "message": {
+              "content": [
+                {
+                  "text": "Hi, how can I help you"
+                }
+              ],
+              "role": "assistant"
+            }
+          },
+          "stopReason": "max_tokens",
+          "usage": {
+            "inputTokens": 8,
+            "outputTokens": 10,
+            "totalTokens": 18
+          }
+        }
+    headers:
+      Connection:
+      - keep-alive
+      Content-Type:
+      - application/json
+      Date:
+      - Thu, 06 Feb 2025 05:12:33 GMT
+      Set-Cookie: test_set_cookie
+      x-amzn-RequestId:
+      - 180bdcbc-0fea-4b99-a0f0-b858dd830a83
+    status:
+      code: 200
+      message: OK
+version: 1
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/tests/test_botocore_bedrock.py b/instrumentation/opentelemetry-instrumentation-botocore/tests/test_botocore_bedrock.py
index a8c0064d1dc..480dc4be863 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/tests/test_botocore_bedrock.py
+++ b/instrumentation/opentelemetry-instrumentation-botocore/tests/test_botocore_bedrock.py
@@ -5,8 +5,11 @@
 
 from __future__ import annotations
 
+import importlib.metadata
 import io
 import json
+import warnings
+from typing import Any
 from unittest import mock
 
 import boto3
@@ -14,15 +17,23 @@
 from botocore.eventstream import EventStream, EventStreamError
 from botocore.response import StreamingBody
 
+from opentelemetry.instrumentation.botocore.extensions.bedrock import (
+    _BedrockRuntimeExtension,
+    _is_genai_bedrock_active,
+)
 from opentelemetry.instrumentation.botocore.extensions.bedrock_utils import (
     ConverseStreamWrapper,
     InvokeModelWithResponseStreamWrapper,
     _Choice,
 )
+from opentelemetry.instrumentation.botocore.extensions.types import (
+    _AwsSdkCallContext,
+)
 from opentelemetry.semconv._incubating.attributes.error_attributes import (
     ERROR_TYPE,
 )
 from opentelemetry.semconv._incubating.attributes.gen_ai_attributes import (
+    GEN_AI_SYSTEM,
     GEN_AI_USAGE_CACHE_CREATION_INPUT_TOKENS,
     GEN_AI_USAGE_CACHE_READ_INPUT_TOKENS,
 )
@@ -3076,3 +3087,126 @@ def get_anthropic_tool_config():
             },
         }
     ]
+
+
+def _create_mock_call_context(
+    operation: str = "Converse",
+    params: dict[str, Any] | None = None,
+) -> _AwsSdkCallContext:
+    mock_client = mock.MagicMock()
+    mock_client.meta.region_name = "us-east-1"
+    mock_client.meta.endpoint_url = "https://bedrock-runtime.us-east-1.amazonaws.com"
+    mock_client.meta.service_model.service_name = "bedrock-runtime"
+    mock_client.meta.service_model.service_id = "Bedrock Runtime"
+    mock_client.meta.service_model.api_version = "2023-09-30"
+    return _AwsSdkCallContext(mock_client, (operation, params or {}))
+
+
+def test_bedrock_runtime_extension_deprecation_warning():
+    call_context = _create_mock_call_context()
+    with pytest.deprecated_call() as warning_info:
+        _BedrockRuntimeExtension(call_context)
+
+    assert any(
+        "The Bedrock extension in 'opentelemetry-instrumentation-botocore' is deprecated" in str(w.message)
+        for w in warning_info
+    )
+
+
+def test_is_genai_bedrock_active():
+    with mock.patch(
+        "importlib.metadata.version",
+        side_effect=importlib.metadata.PackageNotFoundError,
+    ):
+        assert not _is_genai_bedrock_active()
+
+    with mock.patch("importlib.metadata.version", return_value="0.1.0"):
+        assert _is_genai_bedrock_active()
+
+
+def test_bedrock_extension_suppressed_when_genai_active():
+    call_context = _create_mock_call_context(
+        operation="ConverseStream",
+        params={"modelId": "amazon.titan-text-lite-v1"},
+    )
+    with (
+        mock.patch(
+            "opentelemetry.instrumentation.botocore.extensions.bedrock._is_genai_bedrock_active",
+            return_value=True,
+        ),
+        warnings.catch_warnings(record=True) as recorded_warnings,
+    ):
+        warnings.simplefilter("always", DeprecationWarning)
+        extension = _BedrockRuntimeExtension(call_context)
+
+    assert not any(issubclass(w.category, DeprecationWarning) for w in recorded_warnings)
+    assert extension._disabled is True
+    # When disabled, should_end_span_on_exit should be True (standard botocore behavior)
+    assert extension.should_end_span_on_exit() is True
+
+    # setup_metrics should be a no-op
+    metrics: dict[str, Any] = {}
+    extension.setup_metrics(mock.MagicMock(), metrics)
+    assert len(metrics) == 0
+
+    # extract_attributes should be a no-op
+    attributes: dict[str, Any] = {"rpc.system": "aws-api"}
+    extension.extract_attributes(attributes)
+    assert attributes == {"rpc.system": "aws-api"}
+
+    # before_service_call should be a no-op
+    mock_span = mock.MagicMock()
+    mock_ctx = mock.MagicMock()
+    extension.before_service_call(mock_span, mock_ctx)
+    mock_ctx.logger.emit.assert_not_called()
+    mock_span.update_name.assert_not_called()
+
+    # on_success should be a no-op (no stream wrapper, no events, no metrics)
+    result = {"stream": mock.MagicMock(spec=EventStream)}
+    extension.on_success(mock_span, result, mock_ctx)
+    mock_ctx.logger.emit.assert_not_called()
+    assert not isinstance(result["stream"], ConverseStreamWrapper)
+
+    # on_error should be a no-op
+    mock_error = mock.MagicMock()
+    extension.on_error(mock_span, mock_error, mock_ctx)
+    mock_span.set_status.assert_not_called()
+
+
+@pytest.mark.skipif(BOTO3_VERSION < (1, 35, 56), reason="Converse API not available")
+@pytest.mark.vcr()
+def test_converse_suppressed_end_to_end_when_genai_active(
+    span_exporter,
+    log_exporter,
+    metric_reader,
+    bedrock_runtime_client,
+    instrument_with_content,
+):
+    with mock.patch(
+        "opentelemetry.instrumentation.botocore.extensions.bedrock._is_genai_bedrock_active",
+        return_value=True,
+    ):
+        messages = [{"role": "user", "content": [{"text": "Say this is a test"}]}]
+        response = bedrock_runtime_client.converse(
+            messages=messages,
+            modelId="amazon.titan-text-lite-v1",
+            inferenceConfig={
+                "maxTokens": 10,
+                "temperature": 0.8,
+                "topP": 1,
+                "stopSequences": ["|"],
+            },
+        )
+        assert response is not None
+
+    (span,) = span_exporter.get_finished_spans()
+    # Span name should remain the raw botocore RPC span name
+    assert span.name == "Bedrock Runtime.Converse"
+    assert GEN_AI_SYSTEM not in span.attributes
+    assert "gen_ai.request.model" not in span.attributes
+
+    # No gen_ai log events emitted
+    assert len(log_exporter.get_finished_logs()) == 0
+
+    # No gen_ai metrics recorded
+    assert metric_reader.get_metrics_data() is None