Preprocessed EEG data in CLN3 disease and NIH healthy volunteers

This dataset contains preprocessed resting-state EEG recordings from individuals with genetically confirmed CLN3 disease and NIH healthy volunteers.

The EEG data are provided as EEGLAB .set files in BIDS Derivatives format.

Only NIH healthy-volunteer recordings included in the normative EEG analysis are shared here. Collaborating European healthy-volunteer recordings are not included.

Five-minute quiet-wakefulness segments were selected for preprocessing. Segments containing sleep, photic stimulation, or hyperventilation were excluded.

Processing included 1-45 Hz band-pass filtering, 60-Hz notch filtering for NIH recordings, segmentation into 4-second epochs, artifact rejection, and ICA-based removal of ocular, muscular, and electrocardiographic artifacts.

The archived CLN3 preprocessed datasets are stored using a common-average reference. Healthy-volunteer reference information is retained from the corresponding processed EEGLAB datasets.

For the spectral analyses reported in the associated manuscript, posterior channels P3, P4, O1, and O2 were subsequently re-referenced to Fz.

CLN3 public identifiers were reassigned for the combined dataset. NIH healthy-volunteer identifiers correspond to the anonymized HV identifiers used in the normative analysis.