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@lehner-lab

Lehner Lab

Software developed by members of the Lehner lab at the Centre for Genomic Regulation (CRG)

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  1. canya canya Public

    A hybrid neural network to predict nucleation propensity

    Python 12 5

  2. Stop_codon_readthrough Stop_codon_readthrough Public

    Source code for computational analyses and to reproduce all figures in the following publication: Genome-scale quantification and prediction of drug-induced readthrough of pathogenic premature term…

    4

  3. GPCR-MAPS GPCR-MAPS Public

    This repository contains the code to reproduce the analyses presented in the publication "The molecular basis of G-protein coupled receptor signaling" by Taylor Mighell and Ben Lehner

    Jupyter Notebook 2

  4. ABA_receptor ABA_receptor Public

    Forked from MaximilianStammnitz/ABA_receptor

    Companion scripts for DMS data processing, dose-response curve fitting and figure reproduction ("The genetic architecture of an allosteric hormone receptor", Stammnitz & Lehner, Nature Communicatio…

    R 1 1

  5. domainome domainome Public

    16

  6. DiMSum DiMSum Public

    An error model and pipeline for analyzing deep mutational scanning (DMS) data and diagnosing common experimental pathologies

    R 45 8

Repositories

Showing 10 of 51 repositories
  • Programmed_readthrough Public

    Programmed translational readthrough produces C-terminally extended protein isoforms via decoding of stop codons by near-cognate tRNAs. Here we use deep mutational scanning to quantify ~1,400 sequence variants for each of the three examples of human readthrough in the genes AQP4, MAPK10 and OPRK1.

    lehner-lab/Programmed_readthrough's past year of commit activity
    R 0 MIT 0 0 0 Updated Aug 31, 2026
  • MoCHI Public

    Neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data

    lehner-lab/MoCHI's past year of commit activity
    Python 57 MIT 11 2 1 Updated Aug 13, 2026
  • allostery_pathogenicity Public
    lehner-lab/allostery_pathogenicity's past year of commit activity
    Promela 0 MIT 0 0 0 Updated Aug 10, 2026
  • fuzzy_specificity Public

    Code for "A complete map of specificity encoding enables reprogramming of a protein interaction" by Taraneh Zarin, Cristina Hidalgo-Carcedo and Ben Lehner

    lehner-lab/fuzzy_specificity's past year of commit activity
    R 2 MIT 0 0 0 Updated Aug 7, 2026
  • phix174_WGM Public

    Complete mutagenesis of the genome and proteome of ΦX174

    lehner-lab/phix174_WGM's past year of commit activity
    Shell 0 0 0 0 Updated Aug 5, 2026
  • OpenSplice Public

    This repository contains all code to reproduce the analyses and figures in the OpenSplice paper. OpenSplice quantifies the impact of >590,000 variants on the splicing of 608 human exons using massively parallel site-saturation mutagenesis in minigene constructs.

    lehner-lab/OpenSplice's past year of commit activity
    Jupyter Notebook 6 MIT 0 0 0 Updated May 27, 2026
  • TF-MAPS Public

    TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins.

    lehner-lab/TF-MAPS's past year of commit activity
    R 1 MIT 0 0 0 Updated May 11, 2026
  • PDZ_homologs Public
    lehner-lab/PDZ_homologs's past year of commit activity
    HTML 2 MIT 0 0 0 Updated Feb 20, 2026
  • pdzextms Public

    Source code for analyses and to reproduce all figures in the following publication: The effects of PDZ domain extensions on energies, energetic couplings and allostery (Hidalgo-Carcedo C & Faure AJ et al., 2023)

    lehner-lab/pdzextms's past year of commit activity
    R 0 MIT 0 0 0 Updated Jan 29, 2026
  • pdzext Public

    Allosteric and Energetic Remodeling by Protein Domain Extensions

    lehner-lab/pdzext's past year of commit activity
    R 0 MIT 0 0 0 Updated Jan 28, 2026
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