msprime is a population genetics simulator
based on tskit. Msprime can simulate random
ancestral histories for a sample of individuals
(consistent with a given demographic model) under a
range of different models and evolutionary processes. Msprime can
also simulate mutations on a given ancestral
history (which can be produced by msprime or other programs
supporting tskit) under
a variety of genome sequence evolution models.
Please see the documentation for more details, including installation instructions.